Conference paper information

Information-Geometric Selection in T-Cell Receptor Cascades: How Noise Shapes Ligand Discrimination

M. Castro

3rd Biology for Physics Conference - BPC 2026, Barcelona (Spain). 06-10 September 2026

Summary:

We model T cell recognition as Bayesian inference using a universal, unifying framework for existing T-cell phenotypic mechanisms. Antigen discrimination peaks when stochastic encounter durations match internal receptor kinetics. Irreversible commitment steps act as informational filters, maximising mutual information and explaining how physical time constraints shape immune receptor architectures.

Publication date: 06-Sep-2026.

Citation:
M. Castro, "Information-Geometric Selection in T-Cell Receptor Cascades: How Noise Shapes Ligand Discrimination", presented at 3rd Biology for Physics Conference - BPC 2026, Barcelona, Spain, 06-10 September 2026

Research groups:

Instituto de Investigación Tecnológica (IIT)

IIT-26-241C_abstract

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