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Mathematical modeling and inference of virus pathogenesis: an integrated approach

Influenza viruses and coronaviruses have caused some of the deadliest pandemics in humans, and pigs are natural reservoirs. Swine influenza A viruses (swIAV) and porcine respiratory coronavirus (PRCV) are enzootic in pigs, infecting airway epithelial cells. However, they differ in their pathogenicity and the immune response they elicit. Cattle are the natural host for influenza D virus (IDV), but it has recently emerged in swine (swIDV), and its pathogenesis remains unknown. The genetic diversity of swine influenza viruses is enormous and continues to grow, with numerous reassortant genotypes co-circulating and posing a zoonotic threat with proven pandemic potential. The pandemic potential of PRCV and swIDV is still unknown.

In this project we aim to improve our understanding of these important issues through an integrated mathematical model of viral replication, transmission, pathogenesis, and immune control, combined with statistical and machine learning techniques. These approaches will help identify key events in virus-host interactions to inform control strategies.

Our results will contribute to predicting the zoonotic potential, transmission dynamics, and pathogenicity of both existing and emerging swIVs and PRCVs.

 

The contract is part of the action ‘Emerging swine influenza and coronaviruses’ with reference PCI2023-143376, funded by MCIU/AEI/10.13039/501100011033 and co-funded by the European Union.

 

Requirements

Graduate in Physics, Mathematics or Engineering.
A master degree that gives access to Doctorate.
Expertise in mathematical models, simulation and statistical inference.

What do we offer?

A full-time, one-year contract dedicated to the development of this research line. Additionally, the position includes opportunities for training activities. This format allows for a close professional relationship with the institutions involved in the project. The Research Assistant will also have the option to begin a PhD after two years. The predoctoral research contract has an initial duration of one year, renewable for up to six years depending on performance. The gross salary for the first year is €31,472.55 (2025). Furthermore, IIT will cover 90% of the cost of training activities, and the researcher will have full access to all university services and benefits (sports, cultural activities, library, etc.).

Documents

Curriculum vitae, academic transcript, a letter of presentation and motivation. and two letters of recommendation.

Position

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